Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) (N-Term) Peptide
PBX1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN5672303
Aperçu rapide pour Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1) (N-Term) Peptide (ABIN5672303)
Antigène
PBX1
(Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Séquence
- RLMHSHAGVG MAGHPGLSQH LQDGAGGTEG EGGRKQDIGD ILQQIMTITD
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti- PBX1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))
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Sujet
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This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1,19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein Size: 347 -
ID gène
- 5087
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NCBI Accession
- NM_001204963, NP_001191892
Antigène
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